Laboratory tests: A bloodstream level of acetaminophen will aid in identifying if a toxic dosage was taken. The doctor might order several blood degree of acetaminophen, and test for various other drugs taken. Furthermore, the physician may order other blood and urine exams as needed.. Acetaminophen Poisoning Diagnosis A doctor will diagnose acetaminophen overdose with the following methods: History: The doctor will attempt to determine the time and amount of acetaminophen taken. Having access to all medication bottles that the individual may have taken will help the doctor to determine the maximum amount taken. Physical: The doctor can look for signs and symptoms of acetaminophen poisoning. These may include jaundice , abdominal pain, vomiting, and other symptoms and indicators.The ~180-kDa fragment was from a disintegrin and metalloprotease -mediated cleavage, whereas the ~160 – and ~100-kDa fragments were from corin autocleavage. We examined corin shedding in HEK293 cells. Three bands of the predicted sizes were within the conditioned medium from cells expressing WT . In cells expressing the insA variant and the Met-30 isoform, the ~180-kDa fragment was less abundant and the ~100-kDa fragment was barely visible . By densitometric analysis of the Western blots, the %age of the ~180-kDa fragment or all three soluble corin fragments was significantly less than that of WT Western analysis of corin fragments in the conditioned moderate from cells expressing corin WT, the variant and mutants .