The closing of the offering of the Notes is definitely conditioned upon the closing of AMSURG's previously announced acquisition of Sheridan Health care . AMSURG intends to use the net arises from this personal offering, together with its announced registered open public offerings of common share and 5 recently.250 percent Mandatory Convertible Preferred Stock, additional debt financing and cash readily available, to finance the money consideration to be paid to consummate the Sheridan Transaction, as well as repay borrowings under AMSURG's existing revolving credit facility, repay the outstanding stability of its senior secured notes due 2020 and pay fees and expenses linked to the Sheridan Transaction..Patients had been excluded from the scholarly study if they acquired worsening of asthma, respiratory-related visits to the emergency division within 6 weeks before study enrollment, previous use of AMG 157, or known sensitivity to any AMG 157 excipients. Study Design We conducted this proof-of-concept, randomized, double-blind, placebo-controlled study at five centers in Canada. Patients were randomly assigned, in a 1:1 ratio, by means of an interactive voice-response program to receive 700 mg of AMG 157 or placebo in a 1-hour intravenous infusion on study days 1, 29, and 57.