Extra incentives include taxes credits linked to clinical trial expenses, an exemption from the FDA-user fee, and FDA assistance in medical trial design.. Akcea Therapeutics obtains FDA Orphan Drug Designation for volanesorsen Akcea Therapeutics, a wholly-owned subsidiary of Isis Pharmaceuticals, Inc. , announced today that the U.S. Food and Drug Administration has granted Orphan Drug Designation to volanesorsen for the treating patients with Familial Chylomicronemia Syndrome . FCS is usually a rare genetic disease seen as a extremely high triglyceride levels and threat of pancreatitis. In a Phase 2 research published in the NEJM in December 2014, sufferers with FCS treated with volanesorsen achieved significant reductions in apoC-III, triglycerides, chylomicrons and apoC-III-associated suprisingly low density lipoprotein-cholesterol particles.Several categories of drugs will help alleviate the symptoms. Antihistamines will calm runny or itches noses and silence your sneezing. They are not without side effects nevertheless. Many people encounter drowsiness dry mouth or blurry vision. Decongestants are another choice for allergy treatment. They reduce nasal congestion by causing bloodstream vessel constriction and decreased blood flow to the nasal passage. Decongestants may increase blood pressure, cause or aggravate existing heart rhythm abnormalities, and/or cause difficulty asleep falling.