Allergan’s cell-based assay today sets the typical for all the botulinum toxin manufacturers and demonstrates that with dedication and perseverance, you’ll be able to find validated, robust alternative ways of testing medications while maintaining the best level of patient safety. We now call on other companies manufacturing botulinum toxin products, including Ipsen and Merz, to check out Allergan’s ethical lead,’ said Michelle Thew, Chief Executive of the British Union for the Abolition of Vivisection . Until Allergan’s cell-centered assay, the mouse LD50 potency assay provides been the typical for potency and stability testing for all botulinum toxin products and was needed by regulatory agencies all over the world for screening final product for release to assure its basic safety and efficacy.This article was reprinted from with permission from the Henry J. Kaiser Family members Foundation. Kaiser Health News, an editorially independent information service, is a program of the Kaiser Family Foundation, a nonpartisan health care policy research corporation unaffiliated with Kaiser Permanente.. A concerned female with a concealed mole A 38-year-old female presents with a dark brown plaque on the lower abdomen that she feels has changed during the preceding 12 a few months. Can dermoscopy assist in diagnosing this lesion? Case presentation A 38-year-old woman presented for assessment of a pigmented lesion in the lower abdomen that was usually concealed just beneath the top of her underpants. She sensed that the lesion had been present for a true number of years, with some darkening and an increase in proportions over the preceding 12 months.