In razor-sharp contrast, seven weekly doses in excess of 100 mg/kg were perfectly tolerated in HA mice; 100 percent of animals survived, and there have been no significant findings in clinical or anatomic pathology exams toxicologically. Furthermore, single doses as high as 500 mg/kg were perfectly tolerated in both HB and HA mice. Since ALN-AT3 efficacy toward improved hemostasis is accomplished at weekly doses significantly less than 1 mg/kg, these total results support a greater than 100-fold therapeutic index for ALN-AT3 in the hemophilia setting.‘The company hasn’t approved caffeine for use in alcohol consumption.’ FDA officials stressed they have got not reached a summary about the security of beverages like Charge and Joose. Instead they are trying to understand the companies’ legal rationale for advertising the products. ‘There are some unusual safety questions raised by the addition of caffeine to these alcohol consumption,’ said FDA special adviser Mike Taylor. ‘So the burden can be on the companies to supply evidence that works with the final outcome this use is safe.’ The FDA made a decision to do something at the urging of condition attorneys general from New York, California, Maryland and 16 other states, who contend the beverages appeal to underage drinkers and encourage reckless behavior.